Chinese hamster ovary cell

Chinese Hamster Ovary cells (CHO cells) are a cell line derived from Chinese Hamster ovary cells. They are often used in biological and medical research. They were introduced in the 1960s and are used in a cultured monolayer in culture flasks. They require the amino acid proline in their culture medium; this property makes them ideal for genetics research. CHO cells are used in studies of genetics, toxicity screening, nutrition and gene expression particularly expression of recombinant proteins.

See also

References

Tjio J. H., Puck T. T., Genetics of somatic mammalian cells. II. chromosomal constitution of cells intissue culture. J. Exp. Med. 1958; 108: 259-271.

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Cell culture is the process by which either prokaryotic or eukaryotic cells are grown under controlled conditions. In practice the term "cell culture" has come to refer to the culturing of cells derived from multicellular eukaryotes, especially animal cells.
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C. griseus

Binomial name
Cricetulus griseus
Milne-Edwards, 1867

The Chinese Hamster is a species of hamster, scientific names Cricetulus griseus
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For ovary as part of plants see ovary (plants)
An ovary is an egg-producing reproductive organ found in female organisms. They are usually purple. It is often found in pairs as part of the vertebrate female reproductive system.
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Biology (from Greek: βίος, bio, "life"; and λόγος, logos, "knowledge"), also referred to as the biological sciences, is the scientific study of life.
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Medicine is the science and "" of maintaining and/or restoring human health through the study, diagnosis, and treatment of patients. The term is derived from the Latin ars medicina meaning the art of healing.
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Centuries: 19th century - 20th century - 21st century

1930s 1940s 1950s - 1960s - 1970s 1980s 1990s
1960 1961 1962 1963 1964
1965 1966 1967 1968 1969

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Their 1960s decade refers to the years from 1960 to 1969, inclusive.
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A microbiological culture, or microbial culture, is a method of growing a microbial organism to determine what it is, its abundance in the sample being tested, or both. It is one of the primary diagnostic methods of microbiology.
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amino acid is a molecule that contains both amine and carboxyl functional groups. In biochemistry, this term refers to alpha-amino acids with the general formula H2NCHRCOOH, where R is an organic substituent.
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Proline (abbreviated as Pro or P) is an α-amino acid, one of the twenty DNA-encoded amino acids. Its codons are CCU, CCC, CCA, and CCG. It is not an essential amino acid, which means that humans can synthesize it.
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Genetics is the science of heredity and variation in living organisms.[1][2] Knowledge of the inheritance of characteristics has been implicitly used since prehistoric times for improving crop plants and animals through selective breeding.
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Recombinant may refer to :
  • Recombinant DNA - a form of articifial DNA
  • VRLA (also referred to as Recombinant) - valve regulated lead acid, a certain kind of lead-acid battery

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Cell culture is the process by which either prokaryotic or eukaryotic cells are grown under controlled conditions. In practice the term "cell culture" has come to refer to the culturing of cells derived from multicellular eukaryotes, especially animal cells.
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Drug development or preclinical development is defined in many pharmaceutical companies as the process of taking a new chemical lead through the stages necessary to allow it to be tested in human clinical trials, although a broader definition would encompass the entire
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Pre-clinical development is a stage in the development of a new drug that begins before clinical trials (testing in humans) can begin, and during which important safety and pharmacology data is collected.
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Caco-2 refers to a cell monolayer absorption model. Cell-based functional assays, such as the Caco-2 drug transport model for assessing intestinal transport, are extremely valuable for screening lead compounds in drug discovery.
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