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Eleanor "Sis" Daley (March 4, 1907 – February 16, 2003), born Eleanor Guilfoyle, was the wife of former Chicago mayor Richard J. Daley and the mother of the current mayor Richard M. Daley.

Born in the south side Chicago neighborhood of Bridgeport in 1907 as Eleanor Guilfoyle to an Irish family, she met Richard J. Daley in the late 1920s, and after a long courtship they married on June 17, 1936. The Daleys lived in a modest brick bungalow at 3536 South Lowe Street, close to where both had grown up. They had three daughters and four sons, in that order. Their eldest son, Richard M. Daley, was elected mayor of Chicago in 1989, and has served in that position ever since. The youngest son, William M. Daley, served as US Secretary of Commerce from 1997-2000. Another son, John P. Daley, is a member of the Cook County Board of Commissioners.

"Sis" Daley was a quiet woman who seldom spoke out on political matters. One exception was her criticism of "Boss", the 1971 Mike Royko biography of Mayor Daley portraying the mayor in an unfavorable light. Always fiercely protective of her husband and family, her criticism of the book led to one local retailer leaving the book off its shelves. In 1972, developers had obtained the city's tentative approval of a proposal to tear down the old Chicago Public Library downtown and replace it with a modern office tower. Asked her view of the proposal by a Chicago Tribune reporter, Sis Daley observed that she had used the library as a child, and said of the demolition, "I don't think that would be nice." Soon thereafter, a city commission unanimously voted down the project.

Of his wife, the mayor told the press that "She doesn't speak for me and I don't speak for her. She is able to speak for herself very well, whatever she has on her mind." It was said that although her husband may have controlled every aspect of the city's government, "Sis" controlled everything inside their house.

In her later years as a widow and especially during her son's tenure as mayor she became something of a matriarch of Chicago, in fact her birthday of March 4 happens to also be the anniversary of the incorporation of the city. She attended events to honor her late husband at the University of Illinois at Chicago, including the dedication of the university library named after him in 1999 and on the centenary of his birth in 2002. Mrs. Daley died on February 16, 2003 in her Bridgeport home of a stroke 16 days shy of her 96th birthday as her son was running for a fifth term as mayor.