Golgi cell

Information about Golgi cell

Microcircuitry of the cerebellum. Excitatory synapses are denoted by (+) and inhibitory synapses by (-).
MF: Mossy fiber.
DCN: Deep cerebellar nuclei.
IO: Inferior olive.
CF: Climbing fiber.
GC: Granule cell.
PF: Parallel fiber.
PC: Purkinje cell.
GgC: Golgi cell.
SC: Stellate cell.
BC: Basket cell.
Dorlands/Elsevier c_18/12223524
In neuroscience, Golgi cells are inhibitory interneurons found within the granular layer of the cerebellum. These cells synapse onto the soma of granule cells and unipolar brush cells. They receive excitatory input from mossy fibres, also synapsing on granule cells, and parallel fibers, which are long granule cell axons. Thereby this circuitry allows for feed-forward and feed-back inhibition of granule cells.

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Brain: rhombencephalon (hindbrain)
Myelencephalon/medulla
anterior/ventral: Arcuate nucleus of medulla • Pyramid (Decussation) • Olivary body • Inferior olivary nucleus • Anterior median fissure • Ventral respiratory group posterior/dorsal: VII,IX,X: Solitary/tract • XII, X: Dorsal • IX,X,XI: Ambiguus • IX: Inferior salivatory nucleus • Gracile nucleus/Cuneate nucleus/Accessory cuneate nucleus • Area postrema • Posterior median sulcus • Dorsal respiratory group raphe/reticular: Sensory decussation • Reticular formation (Gigantocellular nucleus, Parvocellular reticular nucleus, Ventral reticular nucleus, Lateral reticular nucleus, Paramedian reticular nucleus) • Raphe nuclei (Obscurus, Magnus, Pallidus) tracts: Corticospinal tract (Lateral, Anterior) • Inferior cerebellar peduncle • Olivocerebellar tract • Spinocerebellar (Dorsal, Ventral) • Spinothalamic tract • PCML (Posterior external arcuate fibers, Internal arcuate fibers, Medial lemniscus) • Extrapyramidal (Rubrospinal tract, Vestibulospinal tract, Tectospinal tract)
Metencephalon/pons
Metencephalon/cerebellumVermis • Flocculus • Arbor vitae • Cerebellar tonsil • Inferior medullary velum
Molecular layer (Stellate cell, Basket cell, Parallel fiber) • Purkinje cell layer (Purkinje cell) • Granule cell layer (Golgi cell) • Mossy fibers • Climbing fiber
Deep cerebellar nuclei (Dentate, Emboliform, Globose, Fastigial)
Fourth ventricleapertures (Median, Lateral) • Rhomboid fossa (Vagal trigone, Hypoglossal trigone, Obex, Sulcus limitans, Facial colliculus, Medial eminence) • Lateral recess
An excitatory synapse is a synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell (see also: EPSP)).
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An Inhibitory Postsynaptic Potential (commonly abbreviated as IPSP) is the change in membrane voltage of a postsynaptic neuron which results from synaptic activation of inhibitory neurotransmitter receptors.
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In neuroscience, the term fiber describes a bundle of axons projecting from one group of neurons in a specific area to another. The term may refer to one of two specific mossy fiber locations, which share little similarity aside from their name:

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The deep cerebellar nuclei are four in number on either side

One is of large size, and is known as the nucleus dentatus; the other three, much smaller, are situated near the middle of the cerebellum, and are known as the nucleus emboliformis, nucleus globosus, and nucleus
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The inferior olivary nucleus is the largest nucleus situated in the olivary body, part of the medulla oblongata.

It consists of a gray folded lamina arranged in the form of an incomplete capsule, opening medially by an aperture called the hilum.
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Location Inferior Olive and Cerebellum
Function Unique excitatory function (see text)

Morphology Unique projection neuron (see text)
Presynaptic connections Inferior olive
Postsynaptic connections Purkinje cells

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granule cells refer to tiny neurons (a type of cell) that are around 10 micrometres in diameter. Granule cells are found within the granular layer of the cerebellum, layer 4 of cerebral cortex, the dentate gyrus of the hippocampus, and in the olfactory bulb.
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Parallel fibers arise from granule cells in the cerebellar cortex. They form synapses onto the dendrites of Purkinje cells (the output neurons of the cerebellum).

Granule cells are very small and very numerous.
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Location Cerebellum
Function inhibitory projection neuron

Morphology flat dendritc arbor
Presynaptic connections Parallel fibers and Climbing fibers
Postsynaptic connections Cerebellar deep nuclei

Purkinje cells (or
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In neuroscience, stellate cells are neurons with several dendrites radiating from the cell body giving them a star shapped appearance. The three most common stellate cells are the inhibitory interneurons found within the molecular layer of the cerebellum, excitatory spiny stellate
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Location Cerebellum
Function Inhibitory interneuron

Morphology multipolar
Presynaptic connections Parallel fibers
Postsynaptic connections Purkinje cells

Basket cells
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Elsevier, the world's largest publisher of medical and scientific literature, forms part of the Reed Elsevier group. Based in Amsterdam, the company has substantial operations in the UK, USA and elsewhere.
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Neuroscience is a field that is devoted to the scientific study of the nervous system. Such studies may include the structure, function, evolutionary history, development, genetics, biochemistry, physiology, pharmacology, and pathology of the nervous system.
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An interneuron (also called relay neuron, association neuron or bipolar neuron) is a term used to describe a neuron which has two different common meanings.
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The cerebellum (Latin: "little brain") is a region of the brain that plays an important role in the integration of sensory perception and motor output. Many neural pathways link the cerebellum with the motor cortex—which sends information to the muscles causing them
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granule cells refer to tiny neurons (a type of cell) that are around 10 micrometres in diameter. Granule cells are found within the granular layer of the cerebellum, layer 4 of cerebral cortex, the dentate gyrus of the hippocampus, and in the olfactory bulb.
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In neuroscience, the term fiber describes a bundle of axons projecting from one group of neurons in a specific area to another. The term may refer to one of two specific mossy fiber locations, which share little similarity aside from their name:

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granule cells refer to tiny neurons (a type of cell) that are around 10 micrometres in diameter. Granule cells are found within the granular layer of the cerebellum, layer 4 of cerebral cortex, the dentate gyrus of the hippocampus, and in the olfactory bulb.
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Parallel fibers arise from granule cells in the cerebellar cortex. They form synapses onto the dendrites of Purkinje cells (the output neurons of the cerebellum).

Granule cells are very small and very numerous.
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In animals, the brain or encephalon (Greek for "in the skull"), is the control center of the central nervous system, responsible for behavior. The brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing,
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The rhombencephalon (or hindbrain) is a developmental categorization of portions of the central nervous system in vertebrates.

The rhombencephalon can be subdivided in a variable number of transversal swellings called rhombomeres.
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The myelencephalon is a developmental categorization of a portion of the central nervous system. The myelencephalon is composed of the medulla oblongata; contains a portion of the fourth ventricle; as well as the glossopharyngeal nerve (CN IX), vagus nerve (CN X), accessory nerve
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The medulla oblongata is the lower portion of the brainstem.

Location

By anatomical terms of location, it is rostral to the spinal cord and caudal to the pons, which is in turn ventral to the cerebellum.
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arcuate nucleus is a group of neurons located on the anterior surface of the medullary pyramids. They receive fibers from the corticospinal tract and send their axons through the external arcuate fibers and striae medullares to the cerebellum via the inferior cerebellar peduncle.
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The interior district of the medulla oblongata is named the pyramid and lies between the anterior median fissure and the antero-lateral sulcus.

Its upper end is slightly constricted, and between it and the pons the fibers of the abducent nerve emerge; a little below the
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pyramidal decussation.

Having crossed the middle line, they pass down in the posterior part of the lateral funiculus as the lateral cerebrospinal fasciculus.

Additional images



Diagrams of the medulla spinalis.

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In anatomy, the olivary bodies or simply olives (Latin oliva and olivae, singular and plural, respectively) are a pair of prominent oval structures in the medulla oblongata, the lower portion of the brainstem. They contain the olivary nuclei.
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The inferior olivary nucleus is the largest nucleus situated in the olivary body, part of the medulla oblongata.

It consists of a gray folded lamina arranged in the form of an incomplete capsule, opening medially by an aperture called the hilum.
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The anterior median fissure (ventral or ventromedian fissure) contains a fold of pia mater, and extends along the entire length of the medulla oblongata: it ends at the lower border of the pons in a small triangular expansion, termed the foramen cecum.
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The ventral respiratory group (VRG) is a column of neurons located in the ventrolateral region of the medulla, extending from the caudal facial nucleus to -400μm obex.
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