Spider-Man has one of the best-known rogues galleries in comics. While many of Batman's villains tend to be iconic representations of various concepts, and psychoses (puzzles, comedy, duality, fear, plants, cold, etc.), many of Spider-Man's villains' origins are based in scientific accidents or the misuse of scientific technology, paralleling Spider-Man himself. Likewise, many also have animal-themed costumes or powers. Spider-Man's enemies are some of the best rounded antagonists in comics, with equal emphasis put on both their special abilities and their personalities.

Spider-Man also has a wide range of enemies: hapless thugs, mad geniuses, crime bosses, and even extraterrestrial monsters. Due to the nature of the shared universe he inhabits, he has also fought more closely associated with other heroes. However, these are not considered Spider-Man's own enemies.

The Burglar

Peter Parker's first foe was not one of his more well-known costumed enemies, but rather a common criminal. This unnamed, small-time burglar played a pivotal role in Spider-Man's origin in Amazing Fantasy #15 (August 1962), by writer Stan Lee and artist Steve Ditko. Spider-Man originally intended to use his powers for fame and fortune, but one day he allowed a thief to run past him. Soon after, the same criminal broke into his house intending to rob it and, when confronted, shot and killed Peter's Uncle Ben. After chasing the killer to a warehouse and confronting him, Peter learned, to his horror, that he could have prevented the death by using his powers more responsibly.

The Burglar reappeared in Amazing Spider-Man #170 after serving his term in prison. In issue #200 (January 1980), it is revealed that he had been seeking a large stash of money that was hidden in the Parker house, but unbeknownst to him, it had been destroyed by silverfish years before. When Spider-Man confronted him again (and revealed himself to be Ben Parker's nephew), the burglar was overwhelmed by fear and suffered a fatal heart attack.

He had a daughter named Jessica Carradine, a photographer who has a brief relationship with Spider-Man's clone, Ben Reilly. She believes the murder her father committed was an accident—that the gun Uncle Ben was shot with was his own, which went off by accident during a fight—and that Spider-Man had murdered him. After learning that Ben is Spider-Man, she first threatens to expose him with a photograph she took of him unmasked, but, having witnessed Ben risk his life to save innocent people in a burning skyscraper, decides against it, and gives him the photograph.

Other versions

• Spider-Man's origin is retold in several of his cartoon appearances, and as a result, the burglar is seen in at least one episode each of Spider-Man (1967 TV series), Spider-Man (1981 TV series), Spider-Man and His Amazing Friends and .
• In Ultimate Spider-Man, a reimagining of the Spider-Man mythos, the origin story from Amazing Fantasy #15 is reinterpreted over the course of seven issues. Ben Parker's death at the hands of the burglar does not occur until Ultimate Spider-Man #4. The name "Carradine" appears on a list of "known cat burglars," but nothing else is said about it.
• In the feature film Spider-Man, a robber carjacks Ben Parker and shoots him, rather than breaking into his house. Peter chases him to a warehouse, where the killer trips and falls from a window to his death. The movie credits list the character as "Carjacker", and he is portrayed by Michael Papajohn. Earlier in the film, Peter lets the robber escape as a subtle way of getting revenge against the fight promoter who cheated him out of money, rather than simply thinking it's "not his job" to stop him.
• However in Spider-Man 3, it is also revealed that the carjacker (who is given the name "Dennis Carradine") was not responsible for Ben Parker's death as assumed. The true killer was Flint Marko, who would later become the Sandman. At the climax of the film, Marko confesses to Peter that he accidentally shot Ben when his accomplice Carradine had came out and startled him by grabbing his arm. Carradine stole the car and left Marko behind to take the fall. Marko escaped, however, and so it was Carradine who died for the crime Marko committed. Flint Marko also admits in the movie that he needed the money he stole to help his daughter who was sick, and at the end of the movie, Peter/Spider-Man forgives Flint Marko.

Movie Villains

The three Spider-Man live-action films, directed by Sam Raimi, cover the storylines of perhaps five of Spider-Man's most dangerous villains of all time.

• Green Goblin / Norman Osborn (portrayed by Willem Dafoe) in Spider-Man (also in Spider-Man 2 and Spider-Man 3 , but only as some sort of hallucination)
• Doctor Octopus / Dr. Otto Octavius (portrayed by Alfred Molina) in Spider-Man 2
• New Goblin / Harry Osborn (portrayed by James Franco) in Spider-Man 3 (as a non-villain in Spider-Man and Spider-Man 2)
• Sandman / Flint Marko (portrayed by Thomas Haden Church) in Spider-Man 3
• Venom / Eddie Brock (portrayed by Topher Grace) in Spider-Man 3

Greatest Foes

Spider-Man's most renowned rogues include (in order of appearance):

Villain	First appearance	Description
Chameleon	Amazing Spider-Man #1 (March 1963)	The first supervillain Spider-Man ever faced in print (Supercharger was first chronologically[1]), Dmitri Smerdyakov was a Russian spy with a knack for disguises. Being the half-brother of Kraven the Hunter, he also sought to avenge Kraven's death, become the most powerful crime boss in New York City and utterly destroy Spider-Man with his mind games, including creating the impostors of Peter's parents. He faked his death and was recently a member in the Green Goblin's Sinister Twelve.
Vulture	Amazing Spider-Man #2 (May 1963)	The elderly Adrian Toomes turned to the life of crime after his business partner cheated him. With a self-invented anti-gravity pack, wings for faster flying and a birdlike costume, he became the high-flying, lowdown Vulture. He was briefly transformed into a younger version of himself when he "absorbed" the youth from the android replica of Peter's mother created by the Chameleon, becoming a more challenging foe for Spider-Man. He is a founding member of the Sinister Six and he is currently active after getting out of jail from an anonymous helper to take down Spider-Man during the superhero Civil War.
Doctor Octopus	Amazing Spider-Man #3 (July 1963)	Dr. Otto Octavius is a respected scientist, one of the world's foremost experts in radiation. He used four mechanical arms in his experiments, which bonded with his nervous system after an explosion. He combines physical power with mad genius. He was a founding member and the leader of the Sinister Six. He was partially responsible for the death of George Stacy, among other things, and even led the Masters of Evil at one point. Octavius even became a victim of Spider-Man's insane clone, Kaine, who murdered him, but he was later resurrected by the evil ninja group known as the Hand. He was incarcerated in Riker's Island but escaped when he heard the Green Goblin escaped. The villain confronted the Goblin at the George Washington Bridge and both were struck by electricity, falling into the New York river. Both of them survived and Octavius had remained loose until Peter Parker revealed he is Spider-Man during the superhero Civil War. Octavius attacked Spider-Man and Octavius's arch-nemesis revealed his own face to him. They fought and Spider-Man won, putting Octavius back in jail once more.
Sandman	Amazing Spider-Man #4 (September 1963)	While on the run from the law, the escaped convict Flint Marko found himself on a remote beach during a nuclear weapon testing. His cells were spliced with sand molecules by the created radiation, and his body became a mass of a sand-like substance. He committed many crimes and fought Spider-Man frequently. He was also a hero for some time, until he was brainwashed into being a criminal again.
Lizard	Amazing Spider-Man #6 (November 1963)	When he lost his arm during a war, Dr. Curt Connors felt like he lost a half of himself. Obsessed with regaining his lost limb, Connors created a serum from reptilian DNA, in hope of gaining reptile-like regeneration abilities. He did regain his arm, but at a terrible price: he became a humanoid lizard, with a savage personality. In this form, he fought Spider-Man many times, who managed to cure him of his condition almost every time. The most challenging part of his life right now is living as a single father/widower to his son, Billy, after his wife, Martha, died from radiation poisoning.
Electro	Amazing Spider-Man #9 (February 1964)	An emotionally stunted man with an inferiority complex, Max Dillon was struck by lightning while working on power lines and discovered thereafter that he has a supernatural control over electricity that flows within him. Donning a green and yellow lightning themed costume, he has gone on to battle Spider-Man numerous times. Founding member of the Sinister Six. Electro was one of the Green Goblin's Sinister Twelve members and was last seen captured by the Avengers. A little joke was played in the Spider-Man 2: Daily Bugle Stories (a book based on stories written in the Daily Bugle), about a man who wrote to The Daily Bugle, says he was struck by lightning while working on power lines. He said his name was Max Dillon.
Mysterio	Amazing Spider-Man #13 (June 1964)	A disgraced stunt man and special effects artist named Quentin Beck who donned an extravagant and theatrical costume (notable for its crystal ball like helmet) and sought to discredit and frame Spider-Man using illusions. Mysterio is well known for buying into his own hype, treating every moment as if he is a grand performer on the world's stage. Founding member of the Sinister Six. His student and friend Daniel Berkhart adopted the identity after Quentin Beck's death when he committed suicide when he fought Daredevil. A teleporting mutant named Francis Klum later purchased the Mysterio costume and arsenal from the Kingpin, although he would be later challenged by Berkhart and even Beck himself, who has apparently returned from the dead.
Green Goblin	Amazing Spider-Man #14 (July 1964)	Originally a normal scientist and ambitious businessman, Norman Osborn used an experimental formula which gave him superpowers but also drove him insane. When Spider-Man thwarts his plans to take over as crime boss of New York City, he dedicates himself to utterly destroying Spider-Man's life after learning his secret identity is Peter Parker. Their mutual animosity becomes personal when he kills Gwen Stacy, Parker's long-time girlfriend and first true love. He is also the mastermind behind the Clone Saga, and the leader of the Sinister Twelve. He is imitated by his son, Harry Osborn, and the Hobgoblin and other Green Goblins and Hobgoblins. He has become Spider-Man's arch enemy (with the possible exception of the Burglar) although he has appeared less frequently than some other foes. Green Goblin's powers are extreme agilities, super strength and healing any lethal wound that can kill a normal human being, such as being impaled by his glider after killing Gwen Stacy and among other things. Goblin had also spawned two children with Gwen as Norman Osborn before she died, Gabriel and Sarah, who grew fast within a matter of time and Gwen tried to steal the children away from Osborn, raising them with her boyfriend, Peter Parker, but that is where Goblin killed Gwen. After her death occurred, Osborn manipulated Gabriel and Sarah into thinking it was Spider-Man/Peter Parker who killed their mother and they even tried to kill Spider-Man, although it was soon revealed to both of them about the truth.
Kraven the Hunter	Amazing Spider-Man #15 (August 1964)	Perhaps the most respected big game hunter in the business, Sergei Kravinoff eventually set on a quest to capture the most elusive prey there is - the amazing Spider-Man. After being defeated numerous times by the web-slinger, his quest became an obsession. When he finally did defeat Spider-Man, he felt there was nothing more for him to do, so he committed suicide after setting Spider-Man and Captain America off to chase down the villain known as Vermin. He was a founding member of the Sinister Six and when they were formed together again, the Hobgoblin replaced him. After Kraven died, his half-brother, the Chameleon, became so insane that he honestly thought he was Kraven himself.
Scorpion	Amazing Spider-Man #20 (January 1965)	Private investigator Mac Gargan underwent a process which transformed him into a living weapon capable of destroying Spider-Man. Donning a scorpion-based costume, he set out to defeat Peter Parker numerous times. He has recently bonded with the symbiote formerly used by Eddie Brock to become the new Venom and a member of the Sinister Twelve.
Rhino	Amazing Spider-Man #41 (October 1966)	Aleksei Sytsevich was a poor immigrant from Russia. He participated in an experiment that bonded a super-strong polymer to his skin and gave him enhanced strength, speed, and stamina. He's dim-witted and usually works as an enforcer for more ambitious criminals. Rhino is one of Spider-Man's most powerful foes in terms of physical strength, but his lack of intelligence often gives Spider-Man the upper hand.
Shocker	Amazing Spider-Man #46 (March 1967)	A burglar gifted with a head for engineering, Herman Schultz developed a pair of gauntlets capable of throwing incredibly powerful vibrational blasts. He wears a gold and brown quilted costume to protect himself from the vibrations of his gauntlets. Shocker is one of Spider-Man's most pragmatic and business-minded villains, and usually recognizes his own limitations, even a member of the Green Goblin's Sinister Twelve.
Kingpin	Amazing Spider-Man #50 (July 1967)	Wilson Fisk is the most powerful crime boss in New York City and perhaps the entire east coast, thus becoming a frequent foe of Spider-Man. He allied himself with many supervillains so they can do his bidding, eventually starting a feud with another superhero, Daredevil. Fisk even found out that Daredevil was Matt Murdock and used this information to ruin his life. Murdock is one of Peter's closest friends, so Spider-Man took this very personally and vowed to help Daredevil bring him down. The crime-killing vigilante known as the Punisher is also a foe of Kingpin's. Recently, after learning Spider-Man's identity, Fisk ordered a hit on Peter Parker. Peter's reflexes saved him and Mary Jane, but his Aunt May did not escape the bullet, and remains in critical condition. Peter hunted down the Kingpin and beat him nearly to death in front of many criminal witnesses. destroying his reputation. Peter has promised to return and kill the Kingpin when and if his aunt dies.
Jackal	Amazing Spider-Man #129 (February 1974)	Dr. Miles Warren was an Empire State University biology professor who became infatuated with Peter Parker's girlfriend, Gwen Stacy. After she died during a battle between Spider-Man and the Green Goblin, he became a demented geneticist and cloned both Gwen Stacy and Peter Parker. He gained enhanced strength and agility by combining the genetic material of an actual jackal with his own. His genetic tampering would later result in the Clone Saga.
New Green Goblin	Amazing Spider-Man #136 (September 1974)	Harry Osborn, Norman's son and Peter Parker's best friend, who eventually dons his father's old costume and continues his mission of hate against Spider-Man after his father had presumably died. He later dies due to the serum that gave him powers, but not before saving Spider-Man's life from an explosion, along with Harry's wife, Liz Allan, and his son, Normie.
Hobgoblin	Amazing Spider-Man #238 (March 1983)	A millionaire fashion designer and criminal named Roderick Kingsley acquired the Green Goblin's weaponry and used them to further his own ambitions after the Goblin's seeming death after a battle with Spider-Man. He modified Osborn's original formula to give himself super-human strength without becoming insane. Kingsley later brainwashed Ned Leeds, a reporter working for the Daily Bugle, to act as a stand in on many occasions and fooled the underworld into thinking that Leeds was the Hobgoblin. The mercenary Jason Macendale, as the Jack O' Lantern, had a rivalry with the Hobgoblin and eventually tried to have him assassinated. Kingsley set Ned Leeds to be killed instead and promptly retired as Macendale took over as the Hobgoblin. After repeated failures, Macendale was finally captured and revealed to the public that Ned Leeds was the original Hobgoblin. Kingsley, fearing an investigation, killed Macendale in his prison cell and returned to his role as the Hobgoblin.
Venom	Amazing Spider-Man #299 (April 1988)	When Spider-Man rid himself of the alien symbiote costume he acquired during the Secret Wars, it bonded with reporter Eddie Brock, who hated Spider-Man for causing him to lose his job and reputation. The symbiote gave Brock all of Spider-Man's powers, and even more dangerously, the knowledge of his secret identity and protection from his Spider-Sense. Venom later spawned an even more dangerous villain, Carnage. After having an epiphany, Eddie Brock auctioned the symbiote to the son of a major crime lord, who unsuccessfully attempted to kill Spider-Man and died.
Carnage	Amazing Spider-Man #361 (April 1992)	Carnage is the combination of a symbiote spawned from the original Venom symbiote and the serial killer and former cell mate of Eddie Brock, Cletus Kasady. He thrives on murder and chaos and is many times stronger than Spiderman, but slightly stronger than Venom. To stop him the first few times, Spider-Man had to resort to calling on Venom for assistance. Carnage also created a son, called Toxin who fights on the side of good. Currently, Carnage is presumed dead after an encounter with The Sentry.
Morlun	Amazing Spider-Man vol. 2. #30 (June 2001)	Morlun is from a race called the Ancients, that feed on "totem" people like Spider-Man. While Spider-Man was learning the true intentions of totemistic hunters from his new friend Ezekiel, Morlun became ready for his next hunt: Spider-Man. By creating havoc in the streets of New York, he drew Spider-Man closer to him, and they finally met, and the meeting didn't go too well for Spider-Man. Peter finally put his brains to the test and injected himself with high doses of radiation. When Morlun tried to feed off of Spider-Man now, he grew terribly weaker every instance he was touched. Peter's hunch was correct: He was NOT a pure totemistic force. With Morlun now near death, Spider-Man's decision to kill him was made easier on him when Morlun's "slave" Dex shot Morlun to his death. Recently Morlun returned. This time he overpowered Peter and tore his eye out, feeding on it. Peter was taken to a hospital, but true to form Morlun tracked him down. Peter's wife Mary Jane Watson tried to defend Peter with a scalpel, but Morlun simply broke Mary Jane's arm. Seeing his wife in danger caused something to snap within Peter. He suddenly burst from his bed, his body mutated into a hideous man-spider hybrid. With raw animal aggression he overpowered Morlun, paralyzing him with sharp spikes from his wrists, and sucking the life force out of him with a bite to the throat. A stunned Morlun stammered that things weren't supposed to end this way before dissolving into ashes.

Minor enemies

In alphabetical order:

Villain	First appearance	Description
Angelo Fortunato (Venom)	Marvel Knights Spider-Man #7 (December 2004)	After he found out he has cancer, Eddie Brock, the first Venom, sold his symbiote to Don Fortunato. Angelo Fortunato, the Don's son, became the second Venom for a brief period of time. However, Angelo proved to be a weak host for the Symbiote, being humiliated in a battle with Spider-Man. The Symbiote abandoned Angelo whilst leaping between buildings and the subsequent fall killed him.
Alistair Smythe	Amazing Spider-Man Annual #19 (1985)	The son of Spencer Smythe, the creator of the Spider-Slayers; after his father died of radiation poisoning, Alistair followed in his footsteps, trying to destroy Spider-Man with robots. Crippled after his first attempt at killing Spider-Man, Alistair recently re-gained mobility, as well as superpowers after a combination of self-inflicted mutations and cybernetic implants.
Answer	Lethal Foes Of Spider-Man #4 (July 1984)	Originally a very loyal hit-man of the Kingpin, the Answer eventually became one of his right-hand men. Spying on Spider-Man and the Black Cat was one of his many little odd-jobs. He also retrieved Silvermane where the Kingpin brought him back from the dead. The Answer died after feeding Dagger his "light forces" trying to revive her in order for her to save the Kingpin's wife Vanessa. The Answer became an unconscious being of energy and eventually retained his awareness without any physical form as told in the limited series Lethal Foes Of Spider-Man where he first allied himself with Doctor Octopus communicating with him by means of a computer chip in the good Doctor's mind. The Answer resumed a physical form in issue 2 of that limited series and helped break Doc Ock out of the vault prison. Their friendship quickly turned to hate as they fought each other and the Answer has not been seen since. It was learned that the Answer's real name is David Ferrari when he came back from the "dead" in Captain America V3 #41 but was later defeated in issue #43.
Arcade	Marvel Team-Up #65 (January 1978)	Arcade was born into an extremely wealthy family. At the age of eighteen, his allowance was cut off by his father, who declared that he did not deserve it. In retaliation, Arcade murdered his father, thus inheriting all of the man's vast estate. Now independently wealthy and free to do as he pleased, Arcade designed and built Murderworld, a subterranean evil lair disguised as a very deadly amusement park. For the price of $1 million, he will tailor Murderworld to exploit the specific weaknesses of his target and then watch, with unconcealed glee, as they are killed by the variety of colorful traps strewn throughout the facility. Since his first attempt to slay the unlikely duo of Spider-Man and Captain Britain, Arcade has tangled, at one time or another, with a large number of heroes and teams of heroes.
Armada	Sensational Spider-Man (1988)	Armada was a mercenary hired by Mysterio to steal a large abundance of technology. Though Armada managed to evade Spider-Man temporarily, Spider-Man eventually captured him and sent him to Ryker's Island. Armada later broke free from prison and attempted to get revenge on Spider-Man, only to be beaten senseless and have his armor torn off. Later, Armada escaped from prison once again with the aid of Mysterio. Armada surrendered to Spider-Man in the middle of battle in order to stop Spider-Man from destroying his robots, which he was obsessed with.
Beetle	Strange Tales #123 (August 1964)	Abner Jenkins began his career as a criminal against the Human Torch and the Thing in Strange Tales #123 and eventually went on to battle just about every hero you can name. He met Spider-Man in Amazing Spider-Man #21 and it was the first of many meetings. Alone, or as part of the Sinister Syndicate, the Beetle has proven to be very little trouble to Spider-Man...As well as Daredevil, the Human Torch, the Avengers, Iron Man, well you get the point. He later reformed and joined the Thunderbolts as MACH-I. Having later armor upgrades he is now the MACH-IV.
Big Man	Amazing Spider-Man #10 (March 1964)	Frederick Foswell was a small and timid reporter working for the Daily Bugle who aspired to be a crime boss. Taking on the identity of the Big Man, Foswell and his Enforcers attempted to take over the New York underworld. Though Spider-Man defeated the Enforcers, the Big Man managed to escape, only to be later captured by police. Soon afterwards, Foswell was released from jail and seemingly reformed, working too take down criminals under the alias Patch. Foswell later turned back to crime though, allying himself with the Kingpin. Foswell was later killed when, after betraying the Kingpin, he was shot dead by thugs while protecting J. Jonah Jameson.
	Marvel Team-Up #39 (November 1975)	The daughter of the original Big Man, Janice Foswell sought to follow in the footsteps of her father and gain control of the New York underworld. After she and her Enforcers were defeated by Spider-Man, the Human Torch and Son of the Tiger, Janice was killed by her fiancé, the Crime-Master.
Big Wheel	Amazing Spider-Man #182 (July 1978)	Jackson Weele is a businessman who has embezzled from his company. Fearing that he might be caught, he hires a youthful criminal, Rocket Racer, to steal the evidence that incriminates him. However, Rocket Racer opts to use the evidence to blackmail Weele instead. Despairing, Weele tries to commit suicide, but Rocket Racer prevents him from doing so. However, Racer is not particularly kind to Weele, disparagingly referring to him as "Big Weele". Humiliated by Rocket Racer's taunts, Weele visits the mechanical genius and underworld supplier the Tinkerer, who the Rocket Racer boasted had upgraded his equipment. At Weele's urging, the Tinkerer creates a large metal wheel that can climb up buildings, complete with guns and waldo-arms. With this new vehicle, Wolfman transforms Weele into "Big Wheel", the supervillain. Newly empowered, Big Wheel hunts down and chases Rocket Racer across the city. In the process, he ends up fighting with Spider-Man.
Boomerang	Tales To Astonish #81 (July 1966)	Fred Myers has no superhuman powers, but he has the strength, agility and endurance of a professional athlete from his days as a baseball player. He can throw projectiles with nearly unerring accuracy, and his aim is nearly the peak of what a non-superpowered human can accomplish. Boomerang's most dangerous assets are, naturally, his arsenal of specialized boomerangs. He has modified and improved on them over the years, but the most common ones are exploding boomerangs (with enough explosive power to destroy an automobile), razor-bladed boomerangs, and boomerangs that release large doses of tear gas to disable a target.
Calypso	Amazing Spider-Man #209 (October 1980)	Calypso Ezili, had a complex and mysterious life. She was a psychopathic woman who was associated with Sergei Kravinoff, aka Kraven the Hunter. Calypso seemed to enjoy driving Kraven into fits of rage and furthering his hatred of Spider-Man, which ultimately led to Kraven's suicide. Calypso eventually became a dangerous threat for Spider-Man. The explanation for Calypso's supernatural powers was the sacrifice of her younger sister. She used her abilities to hold Curt Connors, The Lizard, in her grasp, and the two nearly succeeded in murdering Spider-Man. However, the webslinger managed to best them both, and Calypso was apparently killed. Calypso soon returned, and retrieved the Lizard from The Vault so she could control him again. However, the enraged Lizard slashed her throat open and escaped. Her voodoo preventing her from truly dying, Calypso returned again in Spectacular Spider-Man #251-253. Commanding a squad of savages, she attacked Spider-Man and Alyosha Kravinoff, the son of the original Kraven the Hunter. Desiring revenge for losing Sergei, she used her powers to drive Spidey and Alyosha into fighting each other. Spidey and Alyosha fought off her spell, and shared a handshake. Alyosha said that he would hold Calypso at his mansion, so the villainess could tell him about his long-lost father. However, Alyosha slew Calypso instead. Calypso would use her voodoo to survive yet again, her spirit hopping into a series of host bodies. She has come into conflict with Spider-Man and Daredevil, most notably in a series of campaigns involving her enthralled servant Simon Garth, Zombie.
Carrion	Spectacular Spider-Man #25 (December 1978)	The first Carrion was originally an extremely decayed and super-powered clone of Dr. Miles Warren. Blaming Spider-Man for the death of his creator and Gwen Stacy, Carrion tried to kill Spider-Man through the use of a giant amoeba. In the end, Spider-Man escaped the clutches of Carrion, who seemingly perished after being attacked by the amoeba and crushed when the building it was in caught fire and collapsed.
	Spectacular Spider-Man #149 (April 1989)	The second Carrion was a college student named Malcolm McBride who had discovered a genetic virus which mutated him into Carrion, who had all the powers and memories of the original Carrion. Fighting Spider-Man several times, this Carrion briefly aligned with Carnage and his "family" during the "Maximum Carnage" crossover. Eventually Carrion was captured and placed in Ravencroft Institute. Much later, he was broken out by Shriek, who attempted to manipulate him into becoming her "son". In the end, Shriek absorbed the Carrion virus from him, turning him back into Malcolm MacBride. Malcolm, still mentally unstable, was later transformed back into Carrion briefly by Judas Traveller and used him against Spider-Man. Carrion was eventually defeated and later regressed back to Malcolm MacBride.
	Spider-Man: Dead Man's Hand (1997)	While examining the corpse of the Jackal, Dr. William Allen was infected with an extremely powerful version of the Carrion virus. Using its power to manipulate the minds of others, Carrion III went on a killing-spree in New York City. It was only by using the Jackals old scientific notes that Spider-Man managed to cure Dr. Allen of the Carrion plague.
Demogoblin	Web of Spider-Man #86 (March 1992)	The third Hobgoblin, Jason Macendale, wanting power, attempted to sell his soul to the demon N'astirh during the Inferno Crisis. An amused N'astirh declined Macendale's soul and instead grafted a demon to Macendale, "without a catch". Unfortunately for Macendale, the fusion of himself and the demon gave him a hideous appearance and drove him insane. After months of fighting for control of Macendale's body, the demon physically tore himself from Macendale and, christening itself the "Demogoblin", set off to purge the world of "sinners". After facing various heroes such as Spider-Man and Moon Knight as well as briefly allying with Carnage in the Maximum Carnage crossover; the Demogoblin was killed when it was crushed under a church pillar after saving a young child.
Doctor Octopus II	Amazing Spiderman #205	During the Clone Saga, Dr. Otto Octavius was killed by Kaine and was replaced not long after by Carolyn Trainer, daughter of Seward Trainer and adoring student of Octavius. She obtained a set of four tentacles identical to Octavius' and made use of a personal force-field that kept anything from hitting her. (However, her tentacles could lash out from the shield at any time during its use.) She took the name Doctor Octopus in honor of her beloved instructor, the original Dr. Octopus.
Doppelganger	Infinity War #1 (June 1992)	A magically created clone of Spider-Man, the Doppelganger was created by the Magus to kill Spider-Man. Surviving the events of the Infinity War, the Doppelganger, after a brief partnership with the Demogoblin, began to aimlessly wander New York. Eventually coming into contact with Carnage and Shriek, the Doppelganger went on a massive killing spree with the two villains, along with Demogoblin and Carrion II. Eventually the Doppelganger was killed by Carnage while trying to protect Shriek from an attack by him.
Enforcers	Amazing Spider-Man #10 (March 1964)	The Enforcers came together to combine their forces and become a very powerful band of criminals that has been very much in demand by many criminal leaders over the years. None of it's members have super human powers and are self trained.
Fusion	Peter Parker: Spider-Man vol. 2, #30 (June 2001)	Capable of persuading people and manipulating their senses, Fusion was a millionaire who could get anything he wanted. After Fusion's son, Francis, died as a result of trying to imitate Spider-Man, Fusion attempted to take revenge on him. Attacking and brutally beating Spider-Man by morphing his bodyparts into those of various heroes. Capturing and brutally torturing Spider-Man in an abandoned warehouse, Fusion was defeated when Spider-Man, realizing the nature of Fusion's powers, manage to pummel him into submission. When he next appeared, Fusion, having teamed-up with Doctor Octopus, through a bizarre plot of dismembering and mind-controlling people, managed to get a device which allowed him to track Spider-Man. Soon after gaining the device, Fusion was beaten horribly by the traitorous Dr. Octopus and left for dead.
Grey Goblin	Amazing Spider-Man #509	Before her death, Gwen Stacy and Norman Osborn had an affair and Gwen became pregnant with twins: Gabriel and Sarah. Norman took the siblings to France where he raised them, claiming to be their uncle. They believed Peter Parker to be their real father, and were furious that he abandoned them and killed their mother. Gabriel, like his sister, was born with the goblin formula in his system. Due to this, they both age much faster than a normal human; appearing as adults despite being around 9 years old. Gabriel is very much insane, possibly even more so than Norman Osborn.
Hammerhead	Amazing Spider-Man #113 (1972)	Hammerhead is an enemy of Spider-Man and a member of organized crime. He is closely associated with the Maggia crime family. Hammerhead distinguishes himself from other villains in that he dresses up and acts somewhat like a gangster from the 1920s. Due to an injury he suffered in which his skull was reinforced with metal, his head has a flat shape to it.
Hydro-Man	Amazing Spider-Man #212 (January 1981)	Morris Bench worked on a cargo ship until an accident transformed him into a being of pigmented water, able to control his own liquid body. He has since been a member of the Sinister Twelve.
Jack O'Lantern I (Hobgoblin II)	Machine Man #19 (February 1981)	Jason Philip Macendale, was born in Boston, Massachusetts. His original alter ego was Jack O'Lantern, and he wore a flaming pumpkin mask and flew on a disc glider. His first appearance was in Machine Man #19. He battled the aforementioned hero and was soundly defeated. He later moved to make a permanent home in the family of Spider-Man villains, beginning with Spectacular Spider-Man #56. He had no super powers, hurling explosive grenades and hopping about on a "pogo platform". As Hobgoblin, Macendale failed to make any greater mark upon the Underworld.
Kaine	Web Of Spider-Man #119 (December 1994)	Kaine was the first clone of Peter Parker created by Professor Miles Warren who also doubles as the Jackal with only one genetic flaw: He is slowly degenerating due to clone degeneration.
Kangaroo (comics)	Amazing Spider-Man #81 (February 1970)	Frank Oliver was the first Kangaroo but only had two overall appearances in Amazing Spider-Man #81 & 126...#126 showed the Kangaroo off with his "powered-up" powers courtesy of Dr. Jonas Harrow, the man also responsible for Hammerhead's hard head!...Unfortunately, the powers, not to mention Radiation poisoning, got the best of Frank and it killed him.
	Spectacular Spider-Man #242	A second Kangaroo jumped onto the scenes in Spectacular Spider-Man #242 with a very brief humorous appearance that turned out to be a very light workout for Spider-Man...He showed up again as a member of the Legion Of Losers along with teammates Grizzly, Gibbon, & The Spot...These are definitely villains that cause only minor headaches for Spidey, but non the less are extremely entertaining!
Mindworm	Amazing Spider-Man #138	Mindworm was a superhuman mutant with limited telephatic powers who was briefly a minor enemy of Spider-Man. He had an oversized cranium and was naturally extremely intelligent. Eventually, Mindworm attempted to reform but his problems were too difficult for him to control and he allowed himself to be killed by common street thugs to end his great suffering.
Mendel Stromm	Amazing Spider-Man #37 (June 1966)	Stromm was Norman Osborn's college professor, and became his partner in OsCorp Industries. His early research was on a chemical that would provide enhanced strength in its test subjects (and would eventually turn Osborn into the Green Goblin). Osborn, wanting the formula for himself, discovered that Stromm had been embezzling funds from OsCorp, and turned Strom over to the police. After several years in prison, Stromm was released and tried to kill Norman Osborn for revenge using evil robots. He was stopped by Spider-Man and seemingly died of a heart attack. Stromm had made plans for his death, however, by arranging to have his brain waves transferred to a robot double. Now calling himself Robot Master, Stromm returned in Spectacular Spider-Man vol. 1, #68 (July 1982). Spider-Man defeated and destroyed the robot double. Stromm returned again, this time as a cyborg called Gaunt. It was revealed that he survived through a cybernetic suit fused to his body - attached by none other than Osborn. Osborn had discovered that Stromm had survived his heart attack thanks to the Goblin Serum, but on a level of consciousness supported only by his suit. Eventually, via Seward Trainer, he was cured of his need for the suit and came back in a big suit of robotic armor, only for it to be destroyed by Ben Reilly. Shortly afterward, Norman Osborn knocked him out with a laser blast and left him for dead, though he survived and only had amnesia. He came back in yet another robot suit, only to be stopped by Spider-Men yet again.
Queen	Spectacular Spiderman vol.3 #15 (December 2004)	Adriana Soria was the first female marine in combat during World War II. Adriana and a number of other soldiers were exposed to radiation at Bikini Atol in an attempt to create more super-soldiers. All but Adriana died during this experiment. The mental strain of the experiment unhinged Adriana's mind and she was placed in a military asylum and forgotten. Adriana was a latent mutant who's radiated genetic structure made here into an insect human hybrid who still looks completely human. During the events of "Avengers Dissembled", Queen surfaced in New York with the ability to control anyone with "insect genes" including those with retrograde DNA pieces. She battled with Captain America, whom she new from WW II, and Spider-man. She was able to mutate the DNA in Spider-man resulting in his becoming a monstrous spider creature before reverting mostly to his original form. It was Queen's hope that this monstous spider would give birth to a child for her. Spider-man was transformed by the process, gaining greater strength, enhanced senses and the ability to generate organic webs of his own making. Queen was seemingly killed by an explosion when Spider-man defeated her though her body was never found.
Ringer	The Defenders #51 (September 1977)	While breaking into a safe in a building owned by Kyle Richmond, career criminal Anthony Davis was discovered and fought against the hero. During the battle, an angry Nighthawk broke Davis' tooth and was sent to prison. After leaving prison, he decided to hire the Tinkerer, to build him a battlesuit. Upon testing the suit by himself, the Beetle broke into his workshop and the two battled, resulting in Davis becoming the Beetle's prisoner. The Beetle wanted Davis to wear the suit so they could fight Spider-Man together, and convinced Davis to do so because of the deadly explosive weapons built inside the suit. Spider-Man easily defeated the Ringer despite his many weapons and was once again sent to jail. Davis was killed by the Scourge.
Richard Fisk	Amazing Spider-Man #83	Richard Fisk is an anti-hero from the fictional Marvel Universe. He has adopted several identities over the years. Although his goals are noble ones, the methods he uses have caused more harm than good. Richard joined his father's organization, calling himself the Rose, a well-dressed crimelord who always wore a leather mask. However, this was all a ruse to undermine the Kingpin's empire from within. Aiding Richard in this scheme were his good friend Alfredo Morelli and Ned Leeds, who was brainwashed to act as the supervillain the Hobgoblin. However, the Rose's subterfuge resulted in an explosive gang war that tore New York City apart. During a shoot-out Richard shot and killed a police officer, an act that became a turning point for him - no longer could he consider himself morally superior to his father. After Leeds' death and the end of the gang war, Richard resigned himself to his birthright and rejoined the Kingpin's organization as himself.
Seward Trainer	Peter Parker: Spiderman #52	Seward was the Jackal's trusty assistant and the Jackal couldn't have done all of his cloning without him. Having being caught by one of the Green Goblin's Scrier stealing files from his boss, Trainer owned Green Goblin a favour - one that was subsequently called in during the epic battle between Spidey and his Warren made clone.
Shathra	Amazing Spiderman vol.2 #46	Shathra is, much as Spider-Man is rumored to be, a totem of the spider wasp. As spider wasps kill spiders, she escaped the astral world where she lived to find Spider-Man (Spider-Man had previously visited her world and accidentally alerted her to his presence). Her plan was to feed "the spider" to her children once she killed him.
Shriek	Spider-Man Unlimited #1 (May 1993)	Shriek is a dangerous and criminally insane villainess with the ability to manipulate sound. She once allied herself with Carnage and several other supervillains who went about New York on a killing spree. Shriek's origins and real name are uncertain. She was named Sandra Deel in her earliest appearances, but named Frances Louise Barrison in later appearances. Shriek has the ability to manipulate sound in a number of elaborate ways. She can harness it for destructive concussive force or use it to disorient and agitate her enemies. She can apparently hypersonically induce intense emotion in those around her (generating fear, hate, or despair). She also has moderate powers of levitation that she can use to make herself fly and possibly some low level of psionic ability.
Silvermane	Amazing Spiderman #73 (Jun 1973)	Silvio Manfredi, nicknamed "Silvermane" for his near-white hair, is a professional criminal originally from Sicily who has been a long-time nemesis in the Spider-Man comics. He started his criminal career in an organized crime group called the Maggia. Climbing through the ranks and becoming head of the crime family, he eventually formed an alliance with HYDRA, a worldwide organization determined to take over the world. Silvermane has hired many criminals, such as Hammerhead, and he has also been known to be a rival of the Kingpin.
Sin-Eater	Spectacular Spider-Man #107 (Oct 1985)	Well known for his murder of Captain Jean DeWolff, Stanley Carter was injected with drugs while with S.H.I.E.L.D. and had his strength & endurance increased...Able to lift 800 pounds...Extensive hand to hand combat skills...Uses double-barreled shotgun to kill his victims.
Spidercide	(Third Peter Parker) Spectacular Spider-Man #222 (1995); (Spidercide) Spider-Man: Jackal Files #1 (1995)	Spidercide was a Peter Parker clone, Fine-tuned by his creator the Jackal (Miles Warren) to become what evolution would do to Spider-Man over 10,000 years. An amnesiac when accidentally released from his genetic canister, he later believed he was Peter Parker imprisoned for five years. Seeking to protect Mary Jane Watson-Parker against Kaine, Spider-Man (Peter Parker) and the Scarlet Spider (Ben Reilly), Spidercide underwent a genetic transformation into a killing machine triggered by his rage. After an exploding propane truck apparently destroyed him, a Scriers cult member retrieved his remains, restoring him. He returned to the Jackal who costumed him, naming him Spidercide. Infiltrating Genetech Research, he stole a vital ingredient for the Jackal’s Carrion virus and released it in Springville, Pennslyvania, killing thousands. Later joining the Scrier, Spidercide attacked the Jackal but fell from the Daily Bugle building. Pronounced dead, he was placed in stasis where he apparently remains.
The Spot	Spectacular Spider-Man #48 (January 1985)	Jonathon Ohnn can enter himself through holes, or portals to the spot dimension & he can throw them as a weapon from his body, but is limited by the number on him.
Stegron	Marvel Team-Up #19 (March 1974)	Dr. Vincent Stegron was hired by S.H.I.E.L.D to assist Dr. Curt Connors in studying dinosaur DNA from the Savage Land. Stegron stole the DNA samples and injected himself with them. He then transformed into a hominid dinosaur and became bent on reclaiming the earth for the dinosaurs. In addition to Spiderman, he has also ran into conflict with the Black Panther, Ka-zar and both Connors and his alter ego; the Lizard.
Swarm	Champions #14 (July 1977)	As a former Nazi scientist, Fritz Von Meyer hid in South America after World War II. He became very interested in the breeding and keeping of bees. One day he discovered a highly radioactive over-sized beehive due to a meteorite bombardment. The bees that inhabited the hive demonstrated great intelligence. Von Meyer tried to manipulate the bees so that he may train them by using a psionic beam. As a result, the bees underwent even a greater mutation. The bees attacked him and consumed his body in which now only the skeleton existed resulting in a living "Swarm".
Tarantula	Amazing Spider-Man #134 (July 1974)	As a revolutionary terrorist and government operative, Anton Miguel Rodriguez is expelled from his small organization after murdering a guard without reason during a robbery. This is when Anton went on to the other repressive side of the government where they created the identity of the Tarantula for him and to serve as his country's counterpart to Captain America. He clashes with Captain America and Spider-Man and the Punisher.
Terrible Tinkerer	Amazing Spider-Man #2 (May 1963)	Originally thought to be an Alien from Amazing Spider-Man #2, the Tinkerer turned out to really be a brilliant man who is at the top his game in creating mechanical devices & mostly violent ones!...He even equipped the "Spider-Mobile" with weaponry & has had his services employed by many including Big Wheel & Rocket Racer as well as other non-Spidey villains. He also created a Super-Strong robotic assistant named Toy.
Tombstone	Web of Spider-Man #36 (March 1988)	Lonnie Thompson Lincoln was born in Harlem, New York. As Tombstone, he is a superhuman hit man and mob enforcer. He is frequently hired by the Kingpin and has close ties to organized crime and considerable influence within the prison system. Lonnie started out as troubled youth who was bullied by his peers because he was Harlem's only African American albino. He became a school bully, taking protection money. The school newspaper was edited by Joseph "Robbie" Robertson, who was going to run a story on Lonnie's activities but pulled it when Lonnie intimidated him. Unfortunately, Lonnie allowed his personal demons to direct the course of his life and he turned to a life of serious crime.
Vulture II	Amazing Spider-Man #48 (May 1967)	In Amazing Spider-Man #48, "Blackie" Drago, was a prison cellmate of Toomes' who tricked Toomes and stole the Vulture harness and costume which was recently rebuilt. He used the suit to make money through air piracy which ended up in a three-way battle against Spider-Man and Kraven the Hunter which Spider-Man won. He later teamed up with Toomes when escaping from prison. Once free, he was subsequently defeated and humiliated by Toomes whom regained the recognition he deserved. A humbled Blackie was taken away by the police, vowing "I'm through	I'll never put these wings on again!"
Will o' the Wisp	Amazing Spider-Man #167 (April 1977)	Jackson Arvad was born in Scranton, Pennsylvania. A former employee at Roxxon Oil, he worked in the division dedicated to electromagnetic research. Under constant pressure of being fired, Arvad spent lots of time furthering his work on electromagnetism, getting little sleep in the process. He eventually ended up falling asleep on the job, unable to save himself from a laboratory accident that would change his life. He ended up being caught in the electromagnetic field of a device he was working on, the device weakening the electromagnetic attraction between the molecules in his body, threatening his life. When his boss learned of the accident, he decided to let Arvad die, but not before he demanded any scientific applications the device would've had. However, Arvad was able to save himself when he learned he was suddenly able to control the level of attraction between his body's molecules. He attempted to kill his employer multiple times but was stopped each time by either Spider-Man or inadvertently by Tarantula. Finally he opted to simply hypnotize the man into confessing his crimes to the police.

Complete list of enemies

• Anton, a grade 12 student at the gang school Centennial, was last seen in Giant Robots and Spider-Man issue #215
• Agony
• Answer
• Aura
• Basilisk
• Batwing
• Beetle
• The Big Man (Frederick Foswell)
• Big Wheel
• Black Abbott
• Black Fox
• Black Tarantula
• Blizzard
• Boar
• Bomblast
• Boomerang
• Calypso
• Carrion
• Chance
• Coldheart
• Constrictor
• Cyclone
• Delilah
• Demogoblin
• Doctor Zeus
• Doppelganger
• Dr. Mendel Stromm
• Draco
• El Toro Negro
• Electro
• Empathoid
• Enforcers
• The Finisher is an assassin employed by the Red Skull (Albert Malik). He killed Spider-Man's parents. Spider-Man kills him in self defense (Amazing Spider-Man Annual #5) by turning his own missile against him.
• Firearm
• Fixer
• Foreigner
• Vincente Fortunato
• Fusion
• The Ghost
• Gibbon
• Green Goblin (Norman Osborn)
• Green Goblin (Harry Osborn)
• Grey Gargoyle
• Griffin
• Grim Hunter
• Grizzly
• Justin Hammer
• Hammerhead
• Jonas Harrow
• Hitman
• Homo Arachnis
• Human Fly
• Hydro-Man
• Hypno-Hustler first appeared in Spectacular Spider-Man #24 by Bill Mantlo and Frank Springer. He can perform hypnosis with the aid of his guitar, and when teamed with his backup band, The Mercy Killers, can perform mass hypnosis. His boots can emit knockout gas on demand, and have retractable knives in the soles. The Hypno-Hustler also appeared in , a limited series set in the future, at the end of Spider-Man's career.
• Iguana
• Jackal
• Jack O'Lantern
• Jester
• Joystick
• Jury
• Kaine
• Kangaroo
• Kevin Kang
• Kingpin
• Kraven the Hunter
• Alyosha Kravinoff
• Lady Octopus
• Lasher
• Lightmaster
• Living Brain
• The Lizard
• Lobo Brothers
• Looter aka Meteor Man
• Knight & Fogg
• Man Beast
• Man-Bull
• Man-Killer
• Man-Wolf
• Medusa
• Midnight
• Miss Arrow
• Mister Hyde
• Mindworm
• Molten Man
• Morbius the Living Vampire
• Morlun
• Mr. Fear
• Mirage
• Mysterio
• Mysterio (Francis Klum)
• Needle
• New Green Goblin
• Richmond Octavious III
• Overdrive
• The Owl
• Phage
• Polestar
• Proto-Goblin
• Puma
• Ramshot
• Radioactive Man
• Rapier
• Rhino
• Ringer
• Riot
• The Rose
• Roxxon
• Sandman
• Scarecrow
• Scorpia
• Scorpion (Mac Gargan)
• Scorcher
• Scream
• Screech
• Sentry
• Shadrac aka Override
• Shadrac (Gary Dolman)
• Shocker
• Shriek
• Silvermane
• Sin-Eater
• The Sinister Six, Sinister Seven, and Sinister Twelve, teams of Spider-Man's enemies
• The Sinister Syndicate
• Alistair Smythe
• Spencer Smythe
• Speed Demon
• Spider-Slayers (robots)
• The Spot
• Squid
• Stilt-Man
• Gabriel Stacy aka The Grey Goblin
• Sarah Stacy
• Stegron
• Stunner
• Styx and Stone
• Swarm
• Tarantula
• Tatterdemalion
• Taylor, General Orwell
• Thousand
• Tinkerer
• Titania
• Tombstone
• Tracer
• Trapster
• Tri-Sentinel
• Vermin
• Venom (Eddie Brock)
• Venom (Mac Gargan)
• Venom (Angelo Fortunato)
• Vulture
• Walrus
• Senator Ward
• White Rabbit
• Will o' the Wisp
• The Wraith

Non-Spider-Man villains

Spider-Man has fought these people, but they are associated with other characters rather than Spider-Man.

At some points in time, Spider-Man has encountered villains outside of the Marvel universe. Those villains have also been included here, along with the comic company which publishes them. According to Marvel canon, these appearances are technically within a different universe.

• Arcade
• Baron Mordo
• Bella Donna
• Beyonder
• Blackheart
• Bullseye
• Cobra
• Collective
• Doctor Doom
• Dormammu
• Dracula
• Dragon Man
• Firelord
• Gladiator
• Glider (in crossover with Image Comics)
• Graviton
• Grey Gargoyle
• The Hand
• The Joker (in DC Crossover)
• Juggernaut
• Kang the Conqueror
• Kulan Gath
• Lady Deathstrike
• Lex Luthor (in DC Crossover)
• Living Laser
• Llyra
• Madame Hydra
• Magneto
• Mephisto
• Mister Hyde
• Moonstone
• Nitro
• Psycho-Man
• Ra's al Ghul (in DC Crossover)
• Rampage
• Ramrod
• Red Ghost
• Red Skull
• Sauron
• Silver Samurai
• Super-Adaptoid
• Super-Skrull
• Taskmaster
• Thanos
• Ultron
• Wizard
• Zarrko The Tomorrow Man

Vigilantes

Not specifically villains, but Spider-Man has fought these characters regularly as a result of their opposing views on law enforcement. It should also be noted that he has even gone so far as to work alongside most of these characters if only to battle a greater evil.

• Cardiac
• Cloak and Dagger
• Deadpool
• Deathlok
• Disk Jockey
• Elektra
• Prowler
• Punisher
• Razorback
• Rocket Racer
• Silver Sable
• Solo
• Typeface

It should also be noted that, because of his opposition to Superhero Registration and his enrollment in the New Avengers, he is currently at odds with the Mighty Avengers.

Made-For-TV Villains

These villains don't appear in the comics. They were created for the various cartoon series. Among them villains are:

• Arachnoid: He appeared in Spider-Man and his Amazing Friends. Zolton is a chemical scientist who creates a Spider-Serum that will give him Spider-Powers. He impersonates Spider-Man when committing crimes until he mutates into the Arachnoid: a mutant with the torso of a man and a spider's body from the waist down. This plot was somewhat based of Nephilia's.
• Baron Von Rantenraven: He appeared in the 1960s Spider-Man cartoon. He invaded New York with WWII Airplanes.
• Bolton: He appeared in the 1960s Spider-Man cartoon. Bolton is a Martian warrior who can throw thunderbolts. He worked together with Boomer.
• Boomer: He appeared in the 1960s Spider-Man cartoon. Boomer is a criminal who uses bombs. He worked together with Bolton.
• Buzz Mason: He appeared in Spider-Man and his Amazing Friends. He is a S.H.I.E.L.D. agent who secretly controlled Lightwave into committing robberies of a device that will enable him to control a satellite called the GUARDSTAR.
• Charles Cameo: He appeared in the 1960s cartoon. Charles Cameo is a former actor who uses disguises to commit crimes. He once impersonated the Prime Minister of Rutania.
• Clive: He appeared in the 1960s Spider-Man cartoon. Clive is a movie producer who plans revenge on the movie critics and audiences by creating Blotto.
• Cyberiad: He appeared in Spider-Man and his Amazing Friends. Nathan Price was Firestar's lover until an accident caused by an attack by AIM caused him to end up as a cyborg called Cyberiad. He attacked the X-Men Mansion and captured it's members one-by-one. His design is based off Fatal Five member Tharok.
• Desperado: He appeared in the 1960s Spider-Man cartoon. He is a cowboy on a robotic horse.
• Dr. Atlantean: He appeared in the 1960s Spider-Man cartoon. Dr. Atlantean is a scientist from Atlantis who brought Manhattan underwater. He is a redrawn version of the Radiation Specialist.
• Dr. Cool: He appeared in the 1960s Spider-Man cartoon. He is a diamond thief who was robbing diamonds while hiding out in a warehouse with a freezer in it.
• Dr. Magneto: He appeared in the 1960s Spider-Man cartoon. Dr. Matto Magneto is a scientist armed with a gun that can magnetize and de-magnetize objects. He planned revenge upon the world for ridiculing his theories.
• Dr. Manta: He appeared in the 1960s Spider-Man cartoon and he's a Rocket Robin Hood villain. He used giant, mechanical beetles to enslave an island's inhabitants.
• Dr. Noah Body: A brilliant scientist who has somehow found a way to make himself invisible. He has only appeared in the 1960s Spider-Man cartoon.
• Dr. Dumpty: He appeared in the 1960s Spider-Man cartoon. Dr. Humperdink Dumpty is a jewel thief who stole the jewels of actress Rachel Welles when he attacked a parade.
• Dr. Vespian: He appeared in the 1960s Spider-Man cartoon. He is a scientist who developed a drinkable invisibility serum that he tested on himself and his dog.
• Dr. Von Schlick: He appeared in the 1960s Spider-Man cartoon. He is an evil scientist who wears a rubber, non-stick costume with petroleum-based bubbles emitted from his fingers. Spider-Man had to use a special webbing to stop him.
• Dr. Zap: He appeared in the 1960s Spider-Man cartoon. Dr. Zap is an electric-powered Chinese scientist who kidnapped Dr. Irving Caldwell in order to learn the secrets of Dr. Caldwell's levitation helmet.
• Dr. Zelnar: He appeared in the 2003 cartoon. He developed a drug that would make stupid people intelligent. He tested it on thug twins Jack and Mack and used them to commit crimes.
• Fantastic Fakir: He appeared in the 1960s Spider-Man cartoon. He is an Arabian Fakir whose flute can create illusions and control animals.
• Fiddler: He appeared in the 1960s Spider-Man cartoon. Otto is a man who hates rock and roll for it replacing classical music. He used a deadly violin to seek revenge on Cyrus Flintridge.
• Fifth Avenue Phantom: He is quite possibly the most unremarkable villain from the '67 animated series. He appeared in "The Fifth Avenue Phantom" and "The Dark Terrors". He used a device that shrank valuables as well as android women who masqueraded as fashion mannequins.
• Gadgeteer: He appeared in the 1980s Spider-Man cartoon. Gadgeteer is an evil janitor who takes on this identity to steal Dr. Norton's shrink ray.
• The Gaines Twins: They appeared in the 2003 Spider-Man cartoon. Roland and Roxanne Gaines are twins with mind powers who messed with Spider-Man's mind.
• Gamesman: He appeared in the 1980s Spider-Man cartoon. The Gamesman plotted to cause havoc in New York by using the arcade games to hypnotize the teenagers there. He unwittingly caused Francis Byte to become Videoman resulting in Gamesman to manipulate him.
• Harley Clivendon: He appeared in the 1960s Spider-Man cartoon. Harley Clivendon is an Australian who one time hypnotized J. Jonah Jameson with an idol.
• Herbert Landon: :
  Main article: Herbert Landon
• Human Fly Twins: They appeared in the 1960s Spider-Man cartoon. Stan and Lee are former circus acts who reverted to crime.
• Iceberg: He first appeared in the 1994 Spider-Man cartoon. He was a frozen crimelord that works for the Kingpin and that Hobbie Brown used to work for before becoming the Prowler.
• Infinata: He first appeared in the 1960s Spider-Man cartoon and he's a Rocket Robin Hood villain. He's from the Fifth Dimension where he attempted to steal the Universal Encyclopedia from a dying scientist from the destroyed planet Goth.
• Kotep the Scarlet Sorcerer: He first appeared in the 1960s Spider-Man cartoon. Kotep was an ancient Egyptian sorcerer who was defeated by his opponent and placed in suspended animation until a professor at Peter's school used an incantation to awaken him.
• Lightwave: She first appeared in Spider-Man and his Amazing Friends. Aurora Dante is Iceman's half-sister who can manipulate and control light. She is an agent of S.H.I.E.L.D. until Buzz Mason controlled her into stealing a device that will allow Buzz to control the GUARDSTAR. Lightwave is based on Aurora and Darkstar.
• Master Vine: He first appeared in the 1960s Spider-Man cartoon. He is a leader of a race of plant people in an alternate dimension.
• Microman: He first appeared in the 1960s Spider-Man cartoon. Professor Pretories is a diabolical scientist who has a light that can shrink him to a small size.
• Mirium: She first appeared in the 1994 Spider-Man cartoon. In this series, she is a Vampire Queen and the mother of Blade.
• Miss Trubble: She appeared in the 1960s Spider-Man cartoon. She had a chest that enabled her to summon living statue versions of Greek Mythology characters and creatures.
• Mugs Riley: He first appeared in the 1960s Spider-Man cartoon. Mugs Riley is a criminal who escaped from jail and discovered an underground society of Molemen. He used them to commit crimes while disguised as a Moleman.
• Nephilia: He appeared in the 1980s Spider-Man cartoon. Dr. Bradley Shaw and his assistant Penny plotted to attain Spider-Man's blood into order to duplicate his powers use them for Bradley's own needs. Unfortunately, he ends up becoming Nephilia: a mutant with a man's torso and a spider body from the waist down.
• Pardo: He first appeared in the 1960s Spider-Man cartoon. Pardo is a sorcerer who can turn into a black cat and rob people in a movie theatre.
• Parafino: He appeared in the 1960s Spider-Man cartoon. He is the owner of Parafino's Wax Museum. He one time used wax mannequins of Blackbeard the Pirate, Jesse James, and the Executioner of Paris to commit crimes.
• Plotter: He appeared in the 1960s Spider-Man cartoon. Plotter is a criminal mastermind who hires Ox and Cowboy to steal a blueprint for a missile.
• Professor Gizmo: He appeared in the 1980s Spider-Man cartoon. Professor Gizmo is a master criminal who planned to use Spider-Man to attach an antenna to the large sunken treasure ship, the El Conquistador.
• Pterodax: Pterodax appeared in the 2003 Spider-Man cartoon. Pterodax is a high-tech mercenary group led by Sergai.
• Radiation Specialist: He appeared in the 1960s Spider-Man cartoon. The Radiation Specialist took over Manhattan's new and only Nuclear Power Plant and uses a special ray in it to lift Manhattan into the clouds unless the city meets his demands: he is amply paid, granted amnesty from arrest, and permitted to build his own nuclear reactor. He had a radiation gun which gave Spider-Man a disadvantage.
• Scarf: He appeared in the 1960s Spider-Man cartoon. Scarf is a masked villain who uses illusions.
• Shikata: She appeared in the 2003 Spider-Man cartoon. Shikata is a martial arts expert and swordsman who uses a sword and incantation to stay young. She wanted to fight Spider-Man to the finish.
• Sidewinder: He appeared in the 1980s Spider-Man cartoon. Sidewinder is a masked cowboy villain who rides a flying, robot horse. He leads a gang of cowboys who also ride flying, robot horses.
• Skymaster: He appeared in the 1960s Spider-Man cartoon. Skymaster is a criminal that resides in a blimp. He kidnapped the school's football star Roy Robinson so that he can force his father to reveal the invisibility serum's ingredients.
• Stuntman: Stuntman appeared in the 1980s Spider-Man cartoon. Jack Riven was the World's Greatest Stuntman until an accident permanently fused him to a mechanical suit of armor a few years ago. He blames Spider-Man for that. Stuntman has two lackey named Larry and Moe who help make up the Triangle of Evil.
• Super Swami: He appeared in the 1960s Spider-Man cartoon. He is an Oriental-illusionist.
• Talon: She appeared in the 2003 Spider-Man cartoon. Cheyenne Tate is a high-tech thief who was a love interest for Harry Osborne. She is somewhat based on Black Cat.
• Turbo Jet: He appeared in the 2003 Spider-Man cartoon. As Turbo Jet, Wyler acts like a modern-day Robin Hood with the stealing from the rich and giving to the poor while wearing a high-tech suit. He is said to be based on Rocket Racer.
• Videoman: It appeared in Spider-Man and his Amazing Friends. Electro brought it out of an arcade game to steal components for his Ultra-Transformer, but was defeated by the Spider-Friends. Videoman was released again during a thunderstorm. A teenage video game prodigy named Francis Byte ends up becoming Videoman due to an explosion caused by the Gamesman's plot where Francis learns to become a good superhero. After the Gamesman's defeat, he is now training with the X-Men.

References

•  • [ e] Spider-Man
Publications	Main continuity: Amazing Fantasy The Amazing Spider-Man The Sensational Spider-Man The Sensational Spider-Man (vol. 2) Friendly Neighborhood Spider-Man The Spectacular Spider-Man Web of Spider-Man Other continuities: Ultimate Spider-Man Marvel Adventures Spider-Man Spider-Girl Spider-Man Loves Mary Jane
Television	Spider-Man (1967) Spidey Super Stories (1974, live action) Amazing Spider-Man (1978, live action) Supaidāman (1978, Japanese) Spider-Man (1981) Spider-Man and His Amazing Friends (1981) Spider-Man (1994) Spider-Man Unlimited (1999) (2003) The Spectacular Spider-Man (2008)
Films	Spider-Man (2002) Spider-Man 2 (2004) Spider-Man 3 (2007) Future film development
Other topics	Fictional history of Spider-Man Spider-Man supporting characters Spider-Man villains Spider-Man's powers and equipment Video games Alternate versions of Spider-Man Spider-Man in other media