Pedunculopontine nucleus

Information about Pedunculopontine nucleus

Brain:
Latinnucleus tegmentalis pedunculopontinus
NeuroNameshier-495
MeSH Pedunculopontine+Tegmental+Nucleus
Dorlands/Elsevier n_11/12583626
The pedunculopontine nucleus (PPN) (or pedunculopontine tegmental nucleus, PPTN) is located in the brainstem, caudal to the substantia nigra and adjacent to the superior cerebellar peduncle. It is composed by a wide variety of neurochemical cell types, including cholinergic, glutamatergic and GABAergic cells. The PPN has been classically considered as one of the main components of the reticular activating system.

Projections

One of the distinctive characteristics of the PPN is the wide range of its projections. PPN neurons send their axons to several targets in the thalamus, basal ganglia, cerebral cortex, basal forebrain, and lower brainstem. A particularly interesting area for the study of PPN projections is the basal ganglia, due to the high level of interconnectivity between them.The complex receives direct afferences from the medial pallidum.

Functions

The PPN is involved in many functions, including arousal, attention, learning, reward, and locomotion. It is also implicated in the generation and maintenance of REM sleep.

External links

Latin}}} 
Official status
Official language of: Vatican City
Used for official purposes, but not spoken in everyday speech
Regulated by: Opus Fundatum Latinitas
Roman Catholic Church
Language codes
ISO 639-1: la
ISO 639-2: lat
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NeuroNames is a system of nomenclature for the human and/or macaque brain.

It is maintained by the University of Washington and is a part of a tool called "BrainInfo". BrainInfo helps one identify structures in the brain.
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Medical Subject Headings (MeSH) is a huge controlled vocabulary (or metadata system) for the purpose of indexing journal articles and books in the life sciences. Created and updated by the United States National Library of Medicine (NLM), it is used by the MEDLINE/PubMed
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Elsevier, the world's largest publisher of medical and scientific literature, forms part of the Reed Elsevier group. Based in Amsterdam, the company has substantial operations in the UK, USA and elsewhere.
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The brain stem is the lower part of the brain, adjoining and structurally continuous with the spinal cord. Most sources consider the pons, medulla oblongata, and midbrain all to be part of the brainstem.
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The substantia nigra (Latin for "black substance", Soemering) or locus niger is a heterogeneous portion of the midbrain, separating the pes (foot) from the tegmentum (covering), and a major element of the basal ganglia system.
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A synapse is cholinergic if it uses acetylcholine as its neurotransmitter.

Cholinergic means "related to the neurotransmitter acetylcholine", and is typically used in a neurological perspective. The parasympathetic nervous system is entirely cholinergic.
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Glutamic acid or glutamate (abbreviated as Glu or E; Glx or Z represents either glutamic acid or glutamine), is the protonated form of glutamate (the anion). Glutamate is one of the 20 proteinogenic amino acids.
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Gamma-aminobutyric acid (usually abbreviated to GABA) is an inhibitory neurotransmitter found in the nervous systems of widely divergent species. It is the chief inhibitory neurotransmitter in the central nervous system and also in the retina.
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The reticular activating system is the name given to the part of the brain (the reticular formation and its connections) believed to be the center of arousal and motivation in animals (including humans).
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Neurons (also known as neurones and nerve cells) are electrically excitable cells in the nervous system that process and transmit information. In vertebrate animals, neurons are the core components of the brain, spinal cord and peripheral nerves.
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axon or nerve fiber, is a long, slender projection of a nerve cell, or neuron, that conducts electrical impulses away from the neuron's cell body or soma.

Anatomy


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The thalamus (from Greek θάλαμος = bedroom, chamber, IPA= /ˈθæləməs/) is a pair and symmetric part of the brain.
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The basal ganglia (or basal nuclei) are a group of nuclei in the brain interconnected with the cerebral cortex, thalamus and brainstem. Mammalian basal ganglia are associated with a variety of functions: motor control, cognition, emotions and learning.
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cerebral cortex is a structure within the vertebrate brain with distinct structural and functional properties. In non-living, preserved brains, the outermost layers of the cerebrum has a grey color, hence the name "grey matter".
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The basal forebrain is a collection of structures located ventrally to the striatum. Cholinergic neurons in the basal forebrain participate in behavioral processes such as attention and memory.
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The brain stem is the lower part of the brain, adjoining and structurally continuous with the spinal cord. Most sources consider the pons, medulla oblongata, and midbrain all to be part of the brainstem.
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The basal ganglia (or basal nuclei) are a group of nuclei in the brain interconnected with the cerebral cortex, thalamus and brainstem. Mammalian basal ganglia are associated with a variety of functions: motor control, cognition, emotions and learning.
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Arousal is a physiological and psychological state of being awake. It involves the activation of the reticular activating system in the brain stem, the autonomic nervous system and the endocrine system, leading to increased heart rate and blood pressure and a condition of
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Attention is the cognitive process of selectively concentrating on one aspect of the environment while ignoring other things. Examples include listening carefully to what someone is saying while ignoring other conversations in the room (the cocktail party effect) or listening to a
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Learning is the acquisition and development of memories and behaviors, including skills, knowledge, understanding, values, and wisdom. It is the goal of education, and the product of experience.
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Reward may refer to:
  • Bounty (reward)
  • Reward system of psychological account.
  • Loyalty program
  • Reward website

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In a general sense, locomotion simply means active movement or travel, applying not just to biological individuals.
  • In biology, locomotion is the self-powered, patterned motion of limbs or other anatomical parts by which an individual customarily moves itself from

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REM atonia, a state in which the motor neurons are not stimulated and thus the body's muscles don't move. Lack of such REM atonia causes REM Behavior Disorder; sufferers act out the movements occurring in their dreams.
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BrainMaps is an NIH-funded interactive zoomable high-resolution digital brain atlas and virtual microscope that is based on more than 20 million megapixels (50 terabytes) of scanned images of serial sections of both primate and non-primate brains and that is integrated with a
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In animals, the brain or encephalon (Greek for "in the skull"), is the control center of the central nervous system, responsible for behavior. The brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing,
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In biological anatomy, the mesencephalon (or midbrain) is the middle of three vesicles that arise from the neural tube that forms the brain of developing animals. Caudally the mesencephalon adjoins the pons (metencephalon) and rostrally it adjoins the diencephalon
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The tectum (Latin: roof) is a region of the brain, specifically the dorsal part of the mesencephalon (midbrain).

It is derived in embryonic development from the alar plate of the neural tube.
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In the brain, the corpora quadrigemina (Latin for "quadruplet bodies") are the four colliculi—two inferior, two superior—located on the tectum the dorsal aspect of the midbrain.

The corpora quadrigemina are reflex centers involving vision and hearing.
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The inferior colliculi (Latin, lower hill) together with the superior colliculi form the eminences of the corpora quadrigemina, and also part of the tectal region of the midbrain.
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