Pick's disease

Information about Pick's disease


Classification & external resources
ICD-10G31.0, F02.0
ICD-9331.11
OMIM172700
DiseasesDB10034
eMedicineneuro/311 
MeSHD020774
Pick's disease has two meanings that are often confused:

1) Pathology: Neurologists currently use the term "Pick's disease" to mean specifically one of the pathological subtypes of frontotemporal lobar degeneration (FTLD). The pathological hallmark of Pick's disease are Pick bodies. These are spherical cytoplasmic inclusions found within neurons in affected portions of the brain.[1] They cause neurons to swell, taking on a "ballooned" appearance. Pick bodies contain the protein Tau, and hence the disease is also referred to as a tauopathy (along with progressive supranuclear palsy, corticobasal degeneration, and others).

2) Syndrome: Pick's disease is also the old name for the clinical syndrome frontotemporal dementia (FTD). Some neurologists now avoid this use of the term, however, because it is not possible to distinguish between FTD caused by Pick's disease pathology (definition 1) and other FTLD processes prior to autopsy. However, it is important to note that a number of support groups for families of patients with frontotemporal dementia continue to use the name "Pick's disease" in their titles.

Note: This confusion has led some neurologists to suggest other names for FTLD. The most prominent is perhaps Kertesz' suggestion of the term "Pick Complex" to encompass not only the clinical syndromes associated with FTLD, but also the overlapping pathologic processes of corticobasal degeneration and progressive supranuclear palsy.

For more information on Pick's Disease, see the article on the pathologic process of frontotemporal lobar degeneration (FTLD) and its related clinical syndromes of frontotemporal dementia, semantic dementia, and progressive nonfluent aphasia.

References

External links

 •  • [ e]
WHO ICD-10 Mental and behavioural disorders (, )
Neurological/symptomaticDementia (Alzheimer's disease, Multi-infarct dementia, Pick's disease, Creutzfeldt-Jakob disease, Huntington's disease, Parkinson's disease, AIDS dementia complex) - Delirium - Post-concussion syndrome
Psychoactive substanceIntoxication (Drunkenness) - Physical dependence (Alcohol dependence, Opioid dependency) - Withdrawal (Benzodiazepine withdrawal, Delirium tremens) - Amnesic (Korsakoff's syndrome)
Psychotic disorderSchizophrenia (Disorganized schizophrenia) - Schizotypal personality disorder - Delusional disorder - Folie deux - Schizoaffective disorder
Mood (affective)Mania - Bipolar disorder - Clinical depression - Cyclothymia - Dysthymia
Neurotic, stress-related
and somatoform		Agoraphobia - Anxiety disorder - Panic disorder - Generalized anxiety disorder - Social Anxiety Disorder - OCD - Acute stress reaction - PTSD - Adjustment disorder - Conversion disorder (Ganser syndrome) - Somatoform disorder - Somatization disorder - Neurasthenia
Physiological/physical
behavioural		Eating disorder (Anorexia nervosa, Bulimia nervosa) - Sleep disorder (Dyssomnia, Insomnia, Hypersomnia, Parasomnia, Night terror, Nightmare) - Sexual dysfunction (Erectile dysfunction, Premature ejaculation, Vaginismus, Dyspareunia, Hypersexuality) - Postpartum depression
Adult personality
and behaviour		Personality disorder - Passive-aggressive behavior - Kleptomania - Trichotillomania - Voyeurism - Factitious disorder - Munchausen syndrome
Mental retardationMental retardation
Psychological development
(developmental disorder)		Specific: speech and language (Expressive language disorder, Aphasia, Expressive aphasia, Receptive aphasia, Landau-Kleffner syndrome, Lisp) - scholastic skills (Dyslexia, Dysgraphia, Gerstmann syndrome) - motor function (Developmental Dyspraxia)
Pervasive: Autism - Rett syndrome - Asperger syndrome
Behavioural and emotional,
childhood and adolescence onset		ADHD - Conduct disorder - Oppositional defiant disorder - Separation anxiety disorder - Selective mutism - Reactive attachment disorder - Tic disorder - Tourette syndrome - speech (Stuttering, Cluttering)
 •  • [ e]
Nervous system pathology, primarily CNS (, )
Inflammatory diseases
of the CNS		Meningitis (Arachnoiditis) - Encephalitis - Myelitis - Encephalomyelitis (Acute disseminated) - Tropical spastic paraparesis
Systemic atrophies
primarily affecting the CNS		Huntington's disease - Spinocerebellar ataxia (Friedreich's ataxia, Ataxia telangiectasia, Hereditary spastic paraplegia)
Spinal muscular atrophy: Werdnig-Hoffman disease - Kugelberg-Welander disease - Fazio Londe syndrome -
MND (Amyotrophic lateral sclerosis (ALS), Progressive muscular atrophy (PMA), Progressive bulbar, Pseudobulbar, PLS)
Extrapyramidal and
movement disorders		Parkinson's disease - Neuroleptic malignant syndrome - Postencephalitic parkinsonism - Pantothenate kinase-associated neurodegeneration - Progressive supranuclear palsy - Striatonigral degeneration - Dystonia (Spasmodic torticollis, Meige's syndrome, Blepharospasm) - Essential tremor - Myoclonus - Chorea - Restless legs syndrome - Stiff person syndrome
Other degenerative /
demyelinating diseases		Alzheimer's disease - Pick's disease - Alpers' disease - Dementia with Lewy bodies - Leigh's disease - Multiple sclerosis - Devic's disease - Central pontine myelinolysis - Transverse myelitis
Seizure/epilepsyFocal (Simple partial, Complex partial) - Generalised (Tonic-clonic, Absence, Atonic, Benign familial neonatal) - Lennox-Gastaut - West - Epilepsia partialis continua - Status epilepticus (Complex partial status epilepticus)
HeadacheMigraine (Familial hemiplegic) - Cluster - Vascular - Tension
VascularTransient ischemic attack (Amaurosis fugax, Transient global amnesia) - Cerebrovascular disease (MCA, ACA, PCA, Foville's syndrome, Millard-Gubler syndrome, Lateral medullary syndrome, Weber's syndrome, Lacunar stroke)
Sleep disordersInsomnia - Hypersomnia - Sleep apnea (Ondine's curse) - Narcolepsy - Cataplexy - Kleine-Levin syndrome
OtherHydrocephalus (Normal pressure) - Idiopathic intracranial hypertension - Encephalopathy - Brain herniation - Cerebral edema - Reye's syndrome - Syringomyelia - Syringobulbia - Spinal cord compression
For other uses of "ICD", see ICD (disambiguation).


The International Statistical Classification of Diseases and Related Health Problems (most commonly known by the abbreviation ICD
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List of ICD-10 codes. The version for 2007 is available online at [1]

Chapter Blocks Title
I Certain infectious and parasitic diseases
II Neoplasms
III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
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For other uses of "ICD", see ICD (disambiguation).


The International Statistical Classification of Diseases and Related Health Problems (most commonly known by the abbreviation ICD
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The following is a list of codes for International Statistical Classification of Diseases and Related Health Problems. These codes are in the public domain.

See also


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The Diseases Database is a free website that provides information about the relationships between medical conditions, symptoms, and medications.

It directly integrates the Unified Medical Language System.

External links

  • Diseases Database

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eMedicine is an online clinical medical knowledge base that was founded in 1996 by Scott Plantz and Richard Lavely, two medical doctors. It was sold to WebMD in January 2006.
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Medical Subject Headings (MeSH) is a huge controlled vocabulary (or metadata system) for the purpose of indexing journal articles and books in the life sciences. Created and updated by the United States National Library of Medicine (NLM), it is used by the MEDLINE/PubMed
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Pathologist redirects here. For other uses of the terms pathology or pathological, see pathology (disambiguation).


Pathology is the study and diagnosis of disease through examination of organs, tissues, cells and bodily fluids.
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Neurology is a branch of medicine dealing with disorders of the nervous system. Medical professionals (such as Biomedical Doctors and Physicians) specializing in the field of neurology are called neurologists
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MeSH D003704 Frontotemporal lobar degeneration (FTLD) is a pathologic process involving degeneration of gray matter in the frontal lobe and anterior portion of the temporal lobe of the cerebrum, with sparing of the parietal and occipital lobes.
..... Click the link for more information.
Pathologist redirects here. For other uses of the terms pathology or pathological, see pathology (disambiguation).


Pathology is the study and diagnosis of disease through examination of organs, tissues, cells and bodily fluids.
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Pick bodies are silver-staining, spherical aggregations of tau protein in neurons associated with Pick's disease, a subtype of frontotemporal lobar degeneration. Pick bodies were first described by Czechoslovakian neurologist Arnold Pick in 1892.

References

  • Pick A.

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Tau proteins are microtubule-associated proteins that are abundant in neurons in the central nervous system and are less common elsewhere. They were discovered in 1975 in Marc Kirschner's laboratory at Princeton University et al., 1975">http://www.pnas.
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MeSH D024801 Tauopathy is a neurodegenerative disease resulting from the aggregation of tau protein.
Some examples of tauopathies are:
  • Alzheimer's disease
  • Progressive supranuclear palsy
  • Corticobasal degeneration

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Progressive supranuclear palsy
Classification & external resources

ICD-10 G 23.1
ICD-9 333.0

OMIM 601104
DiseasesDB 10723

eMedicine neuro/328  
MeSH D013494 Progressive supranuclear palsy (PSP) (or the
..... Click the link for more information.
Corticobasal degeneration (CBD) is a sporadic progressive neurodegenerative disease associated with atrophy of the cerebral cortex and the basal ganglia. Onset is gradual. The first symptoms usually involve asymmetric changes in motor function, such as dystonia and myoclonus.
..... Click the link for more information.
In medicine and psychology, the term syndrome refers to the association of several clinically recognizable features, signs (discovered by a physician), symptoms (reported by the patient), phenomena or characteristics which often occur together, so that the presence of one feature
..... Click the link for more information.
MeSH D003704 Frontotemporal dementia (FTD) is a clinical syndrome caused by degeneration of the frontal lobe of the brain and may extend back to the temporal lobe. It is one of three syndromes caused by frontotemporal lobar degeneration.
..... Click the link for more information.
autopsy, also known as a post-mortem examination, necropsy, or obduction, is a medical procedure that consists of a thorough examination of a corpse to determine the cause and manner of death and to evaluate any disease or injury that may be present.
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MeSH D003704 Frontotemporal dementia (FTD) is a clinical syndrome caused by degeneration of the frontal lobe of the brain and may extend back to the temporal lobe. It is one of three syndromes caused by frontotemporal lobar degeneration.
..... Click the link for more information.
Corticobasal degeneration (CBD) is a sporadic progressive neurodegenerative disease associated with atrophy of the cerebral cortex and the basal ganglia. Onset is gradual. The first symptoms usually involve asymmetric changes in motor function, such as dystonia and myoclonus.
..... Click the link for more information.
Progressive supranuclear palsy
Classification & external resources

ICD-10 G 23.1
ICD-9 333.0

OMIM 601104
DiseasesDB 10723

eMedicine neuro/328  
MeSH D013494 Progressive supranuclear palsy (PSP) (or the
..... Click the link for more information.
MeSH D003704 Frontotemporal lobar degeneration (FTLD) is a pathologic process involving degeneration of gray matter in the frontal lobe and anterior portion of the temporal lobe of the cerebrum, with sparing of the parietal and occipital lobes.
..... Click the link for more information.
In medicine and psychology, the term syndrome refers to the association of several clinically recognizable features, signs (discovered by a physician), symptoms (reported by the patient), phenomena or characteristics which often occur together, so that the presence of one feature
..... Click the link for more information.
MeSH D003704 Frontotemporal dementia (FTD) is a clinical syndrome caused by degeneration of the frontal lobe of the brain and may extend back to the temporal lobe. It is one of three syndromes caused by frontotemporal lobar degeneration.
..... Click the link for more information.
Semantic dementia (SD) is a progressive neurodegenerative disorder characterized by loss of semantic memory in both the verbal and non-verbal domains. The most common presenting symptoms are in the verbal domain however (with loss of word meaning) and it is therefore often
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Progressive nonfluent aphasia is one of three clinical syndromes associated with frontotemporal lobar degeneration.

Clinical Features

The main clinical features are progressive difficulties with speech production.
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Who Named It? is an English-language dictionary of medical eponyms and the people associated with their identification. Though this is a dictionary, many eponyms and persons are presented in extensive articles with comprehensive bibliographies.
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World Health Organization (WHO) is a specialized agency of the United Nations (UN) that acts as a coordinating authority on international public health. Established on 7 April 1948, and headquartered in Geneva, Switzerland, the agency inherited the mandate and resources of
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List of ICD-10 codes. The version for 2007 is available online at [1]

Chapter Blocks Title
I Certain infectious and parasitic diseases
II Neoplasms
III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
..... Click the link for more information.

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