stratum intermedium

The stratum intermedium in a developing tooth is a layer of two or three cells between the inner enamel epithelium and the newly forming cells of the stellate reticulum. It first appears during the early bell stage of tooth development, at around the 14th week of intrauterine life. The stratum intermedium has a notably high alkaline phosphatase activity. This layer, along with the inner enamel epithelium, is responsible for the tooth enamel formation.

References

  • Cate, A.R. Ten. Oral Histology: development, structure, and function. 5th ed. 1998. ISBN 0-8151-2952-1.
BKB Berkovitz, GR Holland, BJMoxham. Oral Anatomy Histology and Embryology. 3rd edition. Mosby ISBN 0-7234-3181-7
Tooth development is the complex process by which teeth form from embryonic cells, grow, and erupt into the mouth. Although many diverse species have teeth, non-human tooth development is largely the same as in humans.
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The inner enamel epithelium, also known as the internal enamel epithelium, is a layer of cells located on the rim nearest the dental papilla of the enamel organ in a developing tooth. This layer is first seen during the bell stage.
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The stellate reticulum is a group of cells located in the center of the enamel organ of a developing tooth. These cells are star shaped and synthesize glycosaminoglycans. As glycosamingoglycans are produced, water is drawn in between the cells and stretch them apart.
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Alkaline phosphatase (ALP) (EC 3.1.3.1 ) is a hydrolase enzyme responsible for removing phosphate groups from many types of molecules, including nucleotides, proteins, and alkaloids. The process of removing the phosphate group is called dephosphorylation.
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Tooth enamel is the hardest and most highly mineralized substance of the body,[1] and with dentin, cementum, and dental pulp is one of the four major tissues which make up the tooth.
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Amelogenesis is the formation of enamel on teeth and occurs during the crown stage of tooth development after dentinogenesis, which is the formation of dentine. Since dentine must be present for enamel to be formed, this prerequisite is an example of the biologic concept, termed
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